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Moringa oleifera: integrative approach on conventional and traditional Asian medicine

Moringa oleifera: integrative approach on conventional and traditional Asian medicine

By SIYAH ORGANICS Tue, Jul 06, 21


Moringa oleifera L. from the Moringaceae family is a perennial tree widely cultivated in many tropic regions and easily grown even in adverse conditions. M. oleifera is also known as the miracle tree, which for centuries has been indicated for traditional medicine. With no reports of side effects, in doses achievable by ingestion, different parts of M. oleifera is used to treat several conditions, such as malnutrition, diabetes, blindness, anemia, hypertension, stress, depression, skin, arthritis, joints and kidney stones disorders. This plant also showed capacity of helping in maintenance of the cardiovascular system health, blood-glucose levels and providing anti-oxidant, anti-inflammatory and anti-cancer activity as well as the regulation of urinary tract and lactation in nursing women. The seed and leaves powder has water purification properties through flocculation. It also supplements the food in the human diet and in the fortification of livestock feed, especially in developing countries. So, M. oleifera properties have also been applied to cosmetic and byproducts industries due to the high nutritive and protective properties of its seed oil. According to the holistic or traditional medicine, M. oleifera has very relevant therapeutic properties and applications depending on the constitution, somatic and psychological needs of patients. It is usually referred as a natural product that can treat different physical and psychological health aspects, offering an energetic action and structural rebuilder of the body and promoting emotions of highly positive attitudes towards life. The high and specific immunological potential of M. oleifera leads us to suggest an in-depth study to assess the hypothesis of conferring a supportive effect against Covid-19 disease.

Keywords: Moringa oleifera, Drumstick tree, Miracle tree, Medicinal plant, Cosmetics, Food supplement


Moringa oleifera L. (Moringa pterygosperma G.), well-known as the “drumstick” or “horseradish” tree, is native of Northwest India, its main producer, but can also be found in South Africa, Northeast Africa, Madagascar, Tropical Asia, Southwest Asia and Latin America. The Moringa genus comprises 14 species: M. arborea; M. longituba; M. borziana, M. pygmaea; M. hildebrandtii; M. drouhardii; M. longituba; M. peregrina; M. stenopetala; M. rivae; M. ruspoliana; M. Ovalifolia; M. Concanensis and M. oleífera (Rani et al. ). From the Moringaceae family, M. oleifera is the most known, studied and used species (Anwar ; Olson ) with human and animal applications. The various resources obtained from this plant—leaves, flowers, seeds, pods, bark and roots—can be used for cooking or in traditional medicine to treat several pathologies. M. oleifera has the capability to survive in humid or dry hot climates and poor soils (Anwar et al. ; Mainenti ). M. oleifera is a highly nutritious plant, being ideal to treat malnutrition in developing countries (Zongo ; Valdez-Solana et al. ; Gopalakrishnan ; Debajyoti et al. ). M. oleifera gained the title of “Miracle Tree” and commercial attention supported on several properties such as nutritional values, amino acids and flavonols content which can be used in food supplements and cosmetic industry (Tables (Tables1,1, ,2,2, ,33 and and4).4). In fact, when compared to other plants, from 100 g of dry leafs of M. oleifera we can obtain 7 times more vitamin C than from oranges, 10 times more vitamin A than from carrots, 17 times more calcium than in milk, 9 times more protein than in yoghurt, 15 times more potassium than from bananas and 25 times more iron than the obtained from spinach (Oduro et al. ; Rockwood ; Saini et al. ). Table Table11 shows the nutritional values for the edible parts of raw pods and leaves, obtained from the United States Department of Agriculture (USDA) database, although it is known that the nutrient content varies according to the plantation site (Aslam ) and seasons (Witt ). The nutritional value of dried leaves, not existent in USDA database, is presented as an average of values with standard deviation calculated from diverse papers that was compiled and published by Witt (). From leaves to roots, it is possible to obtain good quantities of important minerals, proteins, vitamins, β-carotene, amino acids and phenolic compounds (Anwar et al. ; Leone et al. , ; Saini et al. ; Fahey , ; Debajyoti et al. ; Divya et al. ). M. oleifera extracts have been studied with different medicinal purposes: anti-inflammatory, antihypertensive, diuretic, antimicrobial, antioxidant, antidiabetic, antihyperlipidemic, antineoplastic, antipyretic, antiulcer, and hepatoprotectant (Fahey , ; Abdull Razis et al. ; Divya et al. ). Anwar et al. () published a table with various traditional medicinal uses of the different parts of M. oleifera (Anwar et al. ). The attractive properties of this plant led to studies of side effects and medical interactions in animal models and humans.

Table 1

Nutritional values per 100 g of the edible portion of M. oleifera pods and leaves

Components Per 100 g
Raw podsa Raw leavesa Dried leavesb
Energy (kcal) 37 64 304 ± 87
Water (g) 88.20 78.66 0.0074 ± 0.0029
Protein (g) 2.10 9.40 24 ± 5.8
Total lipid (g) 0.20 1.40 6 ± 2.5
Carbohydrate, by difference (g) 8.53 8.28 36 ± 9.2
Fibre, total dietary (g) 3.2 2.0 20.6–28.6*
Fatty acids, total saturated (g) 0.033
Fatty acids, total monounsaturated (g) 0.102
Fatty acids, total polyunsaturated (g) 0.003
Fatty acids, total trans (g) 0.000 0.000
Cholesterol (mg) 0 0
Vitamin A (RAE) (µg) 4 378 3639 ± 1979.8
Vitamin D (D2 + D3) (µg) 0.0 0
Vitamin D (IU) 0 0
Thiamin (mg) 0.053 0.257 2.6
Riboflavin (mg) 0.074 0.660 1.29–20.5*
Niacin (mg) 0.620 2.220 8.2
Pantothenic acid (mg) 0.794 0.125
Vitamin B-6 (mg) 0.120 1.200 2.4
Vitamin B-12 (µg) 0.00 0.00
Vitamin E (mg) 56–113*
Vitamin C, total ascorbic acid (mg) 141.0 51.7 172 ± 37.7
Folate total (µg) 44 40 540
Folic acid (µg) 0 0
Sodium (mg) 42 9 220 ± 180.0
Potassium (mg) 461 337 1467 ± 636.7
Calcium (mg) 30 185 1897 ± 748.4
Phosphorus (mg) 50 112 297 ± 149.0
Magnesium (mg) 45 42 473 ± 429.4
Iron (mg) 0.36 4.00 32.5 ± 10.78
Zinc (mg) 0.45 0.60 2.4 ± 1.12
Copper (mg) 0.084 0.105 0.9 ± 0.48
Manganese (mg) 0.259 1.063
Selenium (µg) 0.7 0.9

aInformation obtained from United States department of agriculture nutrient database (https://ndb.nal.usda.gov/ndb/foods) in June 2018

bAverage values and standard deviation published by Witt ()

*Only two values were found (Witt )

Table 2

Amino acids and flavonols per 100 g of the edible raw portion of M. oleifera leaves

Per 100 g
Components Raw leaves
Amino acids
 Tryptophan (g) 0.144
 Threonine (g) 0.411
 Isoleucine (g) 0.451
 Leucine (g) 0.791
 Lysine (g) 0.537
 Methionine (g) 0.123
 Cystine (g) 0.140
 Phenylalanine (g) 0.487
 Tyrosine (g) 0.347
 Valine (g) 0.611
 Arginine (g) 0.532
 Histidine (g) 0.196
 Alanine (g) 0.705
 Aspartic acid (g) 0.920
 Glutamic acid (g) 1.035
 Glycine (g) 0.517
 Proline (g) 0.451
 Serine (g) 0.414
 Isorhamnetin (mg) 0.4
 Kaempferol (mg) 6.0
 Myricetin (mg) 0.0
 Quercetin (mg) 16.6

Information obtained from United States department of agriculture nutrient database (https://ndb.nal.usda.gov/ndb/foods) in June 2018

Table 3

Compilation of food supplements containing M. oleifera tree parts or extracts (in June 2018)

Tree parts Brand/Product Product information
Leaves Moringa capsules Regulates the gastrointestinal transit; natural anti-inflammatory; lowers cholesterol levels; improves diabetic condition
Moringa tea Delays the ageing process; ensures proper digestion; high antioxidant power; helps healing process; tonifies body and mind
Moringa kids multivitamin complex Strengthens the immune system; rich in vitamins and minerals; stimulates natural defenses
Moringa powder Adds nutritional value; source of fiber, protein, vitamins and minerals; improves physical condition
Dried seeds extract Moringa capsules Strengthens the immune system; helps to reverse the aging process; beautifies the skin; reduces the appearance of wrinkles and fine lines; maintains the normal glucose level; stimulates brain function and concentration; increases libido
Leaves Moringa syrup
Miracle tree
Leaves Moringa organic tea It is a nutritionally complex whole food naturally rich in vitamins, minerals and amino acids. Daily use of Moringa can help to restore your imbalances in your diet
Organic Moringa superfood supplements—capsules
Moringa Superfood Powder
Moringa Superfood Sticks
Leaves Moringa powder organic The Moringa leaf boasts a vast array of beneficial nutrients, making this tree one of the highest plant sources of vitamins and minerals around
Leaves, dry extract Nutrabasics—Moringa The richness of its active ingredients helps maintain blood glucose levels. Provides Flavonoids (2.5%) and Polyphenols (5%)

Table 4

Compilation of cosmetics containing M. oleifera tree parts or extracts as ingredients (in June, 2018)

Cosmetic ingredients Product brand/name Product information
Leaves Anti-wrinkle face cream Purifying and protective action against environmental stress, such as smoke and pollution
Anti-aging moisturizer face cream
Hand cream
Body milk
M. pterygosperma oil African paradise (body conditioner) Moisturizing, nourishing
Queen bee (hair honey)
Magical Moringa (facial moisturizer)
Charity pot (Hand and body lotion)
Passion fruit (lip balm)
M. pterygosperma leaf infusion/oil Go faster feet (foot lotion)
M. pterygosperma powder Twinkle toes (foot powder) Deodorizing
Lush gardener (cold pressed soap) Remove dirt, moisturizing, nourishing
Laboratoires Sérobiologiques
Active ingredient: peptide from Moringa seeds PURISOFT® Skin cleansing/purification; protects skin against pollution, heavy metals, cigarette smoke
Body shop
M. pterygosperma oil Moringa range (shower gel, oil, body butter, body milk, body sorbet, hand cream, soap, body scrub) Skin feels smooth and restored
M. oleifera leaf extract Moringa eau de toilette Moringa body mist Delicately scent your skin in a crisp, floral aroma with Moringa
M. pterygosperma seed extract Extra-comfort anti-pollution cleansing cream Eliminates traces of pollution, detoxifies the epidermis and protects the skin from the harmful effects of pollution
One-step facial cleanser Neutralizes the effects of pollution and purifies the skin to restore its natural radiance
Exfoliating body scrub Purifies and refines while preserving your skin’s natural moisture balance. Neutralizes the harmful effects of pollution
One-step gentle exfoliating cleanser
Water purify/comfort one-step cleanser
Daily energizer cleansing gel
M. oleifera seeds and oil Moringa soap bio High antioxidant value slowing skin ageing; exfoliate dead cells by regenerating the tissue
Moringa exfoliating face scrub Moringa seeds peel and exfoliate the skin, while Moringa oil moisturizes and regenerates the skin
Moringa O2
M. oleifera leaf extract/oil Herbal moisturizing lotion/facial toner/soap Rejuvenate, nourish and protects skin
herbal shampoo/conditioner Repairs, strengthens, reduces hair fall
Shu Uemura
M. pterygosperma seed extract Anti-Oxi + pollutant and dullness clarifying cleansing oil Enhanced power to remove micro impurities and stubborn make-up; anti-pollution breakthrough
M. pterygosperma extract Urban moisture hydro-nourishing shampoo/conditioner/double serum/deep treatment masque Highly concentrated in nutrients, vitamins and antioxidants intensely hydrates deep within strands
M. oleifera seed extract Anti-pollution micellar cleansing water/gentle cleansing foam/cleansing oil gel/gentle exfoliating gel Removes makeup, pollution particles and excess sebum, while leaving the skin well moisturized. The Seed of Moringa extract selected contains purifying peptides which, on the surface, limit the adhesion of the pollution particles and, in depth, activate their elimination. This extract acts as a protective shield capable of preserving the good bacteria from the cutaneous flora against the aggression of pollution
Dual-phase waterproof eye make-up remover

According the revision by Stohs and Hartman (), until this date none of the human, in vitro studies, or extrapolations of animal studies to humans, reported adverse effects with doses of M. oleifera leaves and leaf extracts achievable by oral ingestion. Although, there was not any report of major adverse side effects, there are some important information that should be registered. In fact, there are some studies suggesting that M. Oleifera cannot be used in combination with other modern medicines in humans. A research by Gholap et al. () concluded that M. oleifera has been noted to be a good regulator of insulin. Thus, according Sileshi et al. (), patients suffering from lack of insulin will probably have adverse reductions of sugar levels when using M. oleifera for medicinal purposes, suggesting that it could decrease the blood sugar to even lower levels when used in combination with other modern medications. Another study suggests that when treating thyroids, M. oleifera compounds of the leaf may improve thyroid function (Tahiliani et al. ), this well proving evidence further suggests that it can possibly conflict with other thyroid medication triggering drug interaction.

A research work concerning the “Acceptability and safety of short-term daily supplementation in a group of malnourished girls” assessed the use, acceptability and safety of M. oleifera on children (girls) in Zambia (Barichella et al. ). With regards to safety concerns, supplementation of 14 g per day of M. oleifera powder was deemed safe for children and adolescents both in the short and long term. This research also noted that mild nausea was reported in 20% of the children at various age groups when meals were supplemented with 20 g of M. oleifera daily showing to be still an inadequate and symptomatic dose in children.

Other studies suggest that M. oleifera could adverse and slowly breaking down the pharmaceutical drugs in the liver and thus, may develop cirrhosis and liver failure resulting in malnutrition and weight loss, as well as decreased cognitive function (Das et al. ; Kelly ; Sileshi et al. ).

Despite the numerous positive health benefits associated with M. oleifera phytochemicals, there are suspicions that it contains harmful substances (Fahey et al. ; Annongu et al. ; Maizuwo ). It contains specific chemical compounds, such as alkaloids and other phytotoxins, which when consumed in high doses presents potentially nerve-paralysing properties and other adverse effects (Maizuwo et al. ). Some of these phytochemicals include moringine, moringinine, estrogen, pectinesterase and phenols including tannin (Fahey et al. ). There are unconfirmed reports that M. oleifera stems, roots and flowers potentially contain harmful phytochemical constituents, especially during pregnancy, which may promote uterus contraction, leading to miscarriages in pregnant women (Dutta ). It is also suspected that it can prevent implantation in women, hence it must be avoided by those attempting to conceive as it functioning as an abortifacient (Nath et al. ; Dutta ). Finally, cytotoxicity was verified in experiments with human peripheral blood mononuclear cells only at 20 mg/kg of an aqueous leaf extract; genotoxicity on blood rat’s cells was verified at 3000 mg/kg (Asare et al. ). However, all mentioned side effects were verified with doses that far exceed the amounts used in food intake (Asare et al. ).

So, research on the adverse side effects with doses achievable by oral ingestion should still go on, since currently there are no scientifically confirmed clear toxic and harmful effects of M. oleifera extracts and products on both human and animal models (Adedapo et al. ; Stohs et al. ).

Many studies on nutrition, phytotherapy disease treatment and prevention goals have been published, thus supporting scientific basis about the efficiency of traditional uses of M. oleifera (Fahey , ). In fact, records about symptoms, signs and treatment strategies in different diseases are found in several ancient texts of traditional medicines such as Ayurveda and Traditional Chinese Medicine (TCM) (Karadi et al. ; Kasote et al. ; Debajyoti et al. ). As an endemic source with highly digestible protein, Ca, Fe, Vitamin C, and carotenoids is considered as a suitable natural product to be used by undernourishment populations (Dixit ).

The resources obtained from M. oleifera tree on a conventional approach

Leaves and pods

In some countries, leaves and fruits are commonly used in culinary as vegetables. Leaves can also be dried and used in infusions or grounded into powder, allowing easier conservation and consumption (Moyo ; Olson et al. ). In all ways of use and conservation, M. oleifera does not lose nutritional value (Mahmood ). Leaves and pods are low in calories and rich in minerals, vitamins and natural antioxidants (Table (Table1)1) (Anwar ; Rebufa et al. ). Phytochemicals like flavonoids are also present in leaves as well as a significant percentage of essential amino acids (Table (Table2).2). M. oleifera leaves contain a high quantity of polyunsaturated fatty acids and low saturated fatty acids content (Moyo ), which combined with diuretic, lipid and blood pressure lowering properties from leaves and pods, contribute to the maintenance of cardiovascular health (Anwar et al. ) (Table (Table5).5). In dried M. oleifera leaves, it was also found a high content in calcium and iron, which is normally residual in other plants used in our diet. In the leaves is found greater a variety and quantity of proteins, when comparing to other tree parts (Rebufa et al. ; Wang et al. ). Due to its nutritional rich values, M. oleifera can be a good enriching food additive to human diet and also an animal feed fortifier (Moyo ). Adding fresh or dried leaves to the feed of milk cows increased milk production (43 and 65% respectively), that fact would be of great importance in developing countries to fight deficiencies in nutrition (Bhargave ). Studies of acceptance by the consumer of enriched foods/snacks with M. oleifera have been obtaining good results (Ellis ; Jung ). M. oleifera can also help lactating mothers produce more milk and help to treat malnutrition in young children. Phytosterols from M. oleifera increase estrogen production that enhance the activity of the mammary glands ducts (Gopalakrishnan ). Doses of 0.042 mg/g of body weight given to mice result in increased milk production. Also, the pup weight augment with increasing doses of M. oleifera leaf powder intake (Titi et al. ; Titi and Nurjanah ). Studies of toxicity in animals show that M. oleifera dried leaf extract might be safe for consumption, although in high doses and prolonged intakes, M. oleifera may cause toxicity by accumulation of some elements (Ali et al. ). The amount of 70 g of M. oleifera dried leaf per day is the maximum recommended doseage (Asiedu-Gyekye et al. ). Table Table33 compiles some food supplements based on M. oleifera tree parts or extracts. A hydroalcoholic extract of green pods increased liver enzymes involved in the detoxification of xenobiotic substances in mice (Table (Table5),5), suggesting a chemo preventive potential of a drumstick extract against chemical carcinogenesis (Bharali et al. ). M. oleifera pods are also valuable to treat digestive and obesity problems and thwart colon cancer (Gopalakrishnan et al. ). β-carotene, the major component reported from the drumsticks of the M. oleifera plant as well as the presence of vitamin A and C suggest an action in the induction of antioxidant and anti-inflammatory profiles (Geervani and Devi 1981; Bharali et al. ; Praengam et al. ). It was suggested that β-carotene and sterols present in the plant pods acts as potent inhibitors on the formation of reactive oxygen intermediates, a pre-requisite for tumorigenesis and so inducing apoptosis in the mouse colon carcinoma model (Gupta et al. ; Kraiphet et al. ).

Table 5

Summary table of pharmacological actions of different M. oleifera tree parts such us leaves, pods, seeds, flowers, roots and bark according to conventional principles

Pharmacological actions of M. oleifera
Leaves Increase lactation and estrogen precursor production Treatment of tiphoid and malaria diseases Cerebrovascular neuroprotectant; nervous disorders as hysteria; Cognitive enhancer. Anti-depressant in combination with SSR Anti-tumor in cancer; anti-rheumatism; anti- bacterial and viral infection;
(Titi et al. ; Titi and Nurjanah ; Sa’roni et al. ; Gopalakrishnan et al. ) (Udosen et al. ; Donkor et al. ; Dondee et al. ) (Vauzour et al. ; Kirisattayakul et al. ; Fahey ; ) (Sutalangka et al. ; Kaur et al. ) (Fahey ; )
Animal model In vitro studies Animal model Animal model Animal model
p  <  0.05 p  <  0.05 p  <  0.05 p  <  0.05 N/A
Increase circulating neutrophils in acute stress Reduction on post prandial blood glucose Increase insulin Positive impact on lipid profile Antioxidant activity
(Drue et al. ) (Ghiridhari ; William ) (Anthanont et al. ) (Nambiar ) (Verma et al. )
Animal model Human model Human model Human model In vitro and Animal model
p  <  0.05 p  <  0.05 p  <  0.05 p  <  0.05 p  <  0.05
Antibacterial properties in hand-washing equal to soap and clear different of the control group Anti-cancer activity against breast and colorectal carcinomas Wound healing of aqueous extracts Skin anti-aging Reduction in skin sebum production
(Torondel et al. ) (Al-Asmari et al. ; Gopalakrishnan et al. ) Muhammad et al.  (Ali et al. ) (Ali )
Human model In vitro studies In vitro studies Human model Human model
p  <  0.05 p  <  0.05 p  <  0.05 p  <  0.05 p  <  0.05
Increase in skin hydration Anti-wrinkles Reduce in skin erythema Regulate hyperthyroidism Decrease of acute lung inflammation
(Ali ) (Ali et al.  (Ali ) (Tahiliani et al. ) (McKnight et al. )
Human model Human model Human model Animal model Animal model
p  <  0.05 p  <  0.05 p  <  0.05 p  <  0.05 p  <  0.05
Pods Chemopreventive potential in hepatic and spleen cancer Treat diarrhea and joint pain Induce apoptosis in colon carcinoma Anti-inflammatory; antioxidant and detoxification Decrease of lipid peroxidation and reactive oxygen intermediates,
(Bharali et al. ; Gopalakrishnan ) (Gopalakrishnan et al. ) Kraiphet et al.  (Bharali et al. ) Dasgupta and De ; Bharali et al. 
In vitro studies N/A Animal model Animal model Animal model
p  <  0.05 p  <  0.05 p  <  0.05 p  <  0.05 p  <  0.05
Seeds Skin nourishing, moisturizing, antioxidant, protective, cleansing Anti-diabetic, antioxidant, and antiarthritic properties Antimicrobial activity Inhibit induced hepatotoxicity; ameliorated liver fibrosis; reduce hepatic activity myeloperoxidase Increased and ameliorated all kidney functions parameters
(Nadeem and Imran ) (Mahajan et al. ; Al-Malki and El Rabey ) (Viera et al. ) (Hamza ; ) (Al-Malki and El Rabey )
Human model Animal model In vitro studies Animal model Animal model
N/A p  <  0.05 p  <  0.05 p  <  0.05 p  <  0.05
Flowers Hypocholesterolemic and cure urinary problems Anti-cancer activity in androgen independent models of prostate cancer Hepatoprotective on paracetamol—induced hepatotoxicity Promote intestinal motility and laxative effects improved lipid profile and prevented weight gain
(Gopalakrishnan et al. ) (Inbathamizh ) (Ruckmani ) (Guiguer et al. ) (Guiguer et al. )
N/A In vitro studies Animal model Animal model Animal model
p < 0.05 p < 0.05 p < 0.05 N/A
Roots Hepatoprotective on Paracetamol—Induced Hepatotoxicity Anti-inflammatory Anti-implantation effect Anti-ulcer, antisecretory, and cytoprotective activity Reduce the urinary oxalate and the stone deposition in the kidneys
(Ruckmani ) (Cáceres ) (Shukla et al. ) (Choudhary et al. ) (Karadi et al. )
Animal model Animal model Animal model Animal model Animal model
p  <  0.05 p  <  0.05 p  <  0.05 p  <  0.05 p  <  0.05
Bark Antifungal against Neurospora Antibacterial Management of urinary tract infections symptoms Anticholesteremic and antilipidemic Hepatoprotec-tive
(Jha ) (Zaffer et al. ) (Maurya and Singh ) (Senecha ) (Kurma )
In vitro studies In vitro studies Human model Animal model Animal model
p  <  0.05 N/A p  <  0.05 p  <  0.05 p  <  0.05

Studies with statistically significant value are represented by p < 0.05; a non-applicable/not found values are represented by N/A

Studies in rats showed that M. oleifera leaves extract might act as potential neuroprotectant via decreased oxidative stress and the enhanced cholinergic function (Kirisattayakul et al. ) and function as a cognitive enhancer, hence being used in dementia cases (Sutalangka et al. ). It was also found an anti-depressant activity in mouse models of depression when giving orally a 200 mg/kg/day of a M. oleifera alcoholic extract plus 10 mg/kg/day fluoxetine, for 14 days (Kaur et al. ). This effect can be increased when combined with fluoxetine (as a selective serotonin reuptake inhibitor—SSRI) according to Sutalangka et al. () and Kaur et al. ().The influence of M. oleifera may be due to the action of antioxidants and flavonoids through radical scavenging, since its action is verified in other studies on animal models with cerebrovascular diseases exerting a multiplicity of neuroprotective actions within the brain and suppressing neuro-inflammation and thus suggesting a great potential to promote memory, learning and cognitive function (Vauzour et al. ).

Other studies with consumption of M. oleifera leaf powder revealed properties in human an animal models such as decreased blood glucose levels on diabetic type two subjects (William ), reduction on post prandial blood glucose (Ghiridhari ), increased insulin secretion in healthy subjects (Anthanont et al. ), decreased total plasma cholesterol and increased HDL (Nambiar ). The presence of β-sitosterol in M. oleifera leaves may be one of the reasons for decreasing plasma cholesterol since phytosterols cause less intestinal absorption of dietary cholesterol and increase its excretion on feces (Jain ; Mbikay ). Several M. oleifera studies with leaf powder or extracts on animals revealed other properties beyond the previously referred: antioxidant, chemoprotectant and antihypertensive (Stohs and Hartman ). The antioxidant activity derives from the high amounts of polyphenols (Leone et al. , ; Verma et al. ). Leaves extracts have revealed anti-cancer properties with anti-neoproliferative activity by inducing Reactive Oxygen Species ROS production only in cancer cells which leads to cell apoptosis (Gopalakrishnan ). The active compounds present in extracts from leaves and bark revealed anti-cancer activity against breast and colorectal cancer cell lines through diverse mechanisms as decreased cell mobility, decreased colony formation, low cell survival, high apoptosis and G2/M enrichment (Al-Asmari et al. ). Some extract fractions with anticancer activity have already been isolated, characterized and tested in vitro and in vivo (rat model) (Krishnamurthy et al. ) (Table (Table55).

In traditional medicine, a paste made of leaves is applied externally in wounds (Siddhuraju and Becker ). Some scientific studies have shown that leave extracts have beneficial properties in skin. Aqueous leaves extract increased human dermal fibroblasts proliferation leading to faster wound healing (Muhammad et al. ). A M. oleifera leave extract fraction with ethyl acetate, in low concentration (12.5-50 µg/ml), showed in vitro effect in skin healing by increasing proliferation of human dermal fibroblasts (Gothai et al. ). A hydroalcoholic extract of M. oleifera leaves used in a cream showed antiaging characteristics due to phenolic compounds. Sunscreen and photo protective characteristics were studied very recently (Baldisserotto et al. ). When applying a cream with this extract it was also verified a reduction in sebum production (Ali et al. , , ) (1), and in transepidermal water loss allowing to increase hydration (Ali et al. , , ) (2). Wrinkles and other signs of lack of skin vitality where improved during 3 months of using the same topic formulation with M. oleifera leaf extract (Ali et al. ). The compounds responsible for this improvement in skin surface appear to be phenolics (e.g., kaempferol and quercetin) and antioxidants such as vitamins A, C and B (Jadoon et al. ). M. oleifera leaf extract cream was also tested for potential skin irritation by a 48 h semi-occluded patch test and proved to be non-irritant and well accepted by the volunteers, also reducing skin erythema (Ali et al. , , ) (3) (Table (Table5).5). M. oleifera leaf powder can be used to clean hands when four grams of wet (more efficient) or dried powder are applied on hands and rubbed (Torondel et al. ). The efficacy results were the same as for non-medicated soap, revealing potential to help in hand hygiene and prevent pathogen transmission in developing countries, where hygiene products are scarce.

A leave extract sprayed in plant crops revealed another utility for this plant, having beneficial effects on the growing rate, size and resistance on those plants and fruits (Bhargave ). M. oleifera leaf tea studies demonstrated alterations in blood circulating neutrophils and conclude that Moringa tea has adaptogenic capabilities in cases of stress (Drue et al. ) (Table (Table5).5). Previous studies using dried Moringa leaves tea in mouse model with acute lung inflammation, showed that mice that had decreased lung inflammation marked by alterations in cytokine production, leukocyte migration, and neutrophil apoptosis (McKnight et al. ). An ethanolic extract of Moringa leaves has anti-anxiety effect in swiss albino mice, the ethanolic extract of M. oleifera leaves may have produced its anxiolytic effects via multiple mechanisms (Bhat ).


Seeds, collected from pods, can be eaten raw or cooked. From M. oleifera seeds, a rich vegetable oil can be produced. M. oleifera seed oil or Behen/Ben oil is produced through the cold pressing of the M. oleifera seeds. M. oleifera oil can be used to cook, as a source to prepare biodiesel, as a lubricant and in the cosmetic industry (Rashid et al. ). The oil name comes from its high content on behenic acid, which confers more resistance to oxidative degradation comparing to other vegetable oils. Ben oil is rich in oleic acid (up to 76%), palmitic (6.54%), but also stearic (6%), behenic (7%), and arachidic (4%) (Anwar ). It is used in various cosmetic formulations as emollient and confers nourishing, moisturizing, antioxidant and protective properties. It is also a good skin cleansing product (Nadeem and Imran ). Table Table44 details some cosmetic brands that use M. oleifera leaves, oil or active extracts as ingredients in the composition of their products. This oil is also used in the enfleurage process, allowing the extraction of fragrances and active compounds from difficult sources as flower petals. Milled M. oleifera seed shells can be used as a natural exfoliating agent.

Moringa oleifera seeds can also help diabetic patients (Table (Table5).5). Some studies by Al-Malki and El Rabey () showed its anti-diabetic activity by reducing the blood glucose level when rats where treated with 50 or 100 mg of M. oleifera seeds powder/kg body weight, during 4 weeks. At the same time, ingestion lead to an increase in antioxidant enzymes and consequently the compound content such as glucomoringin, phenols, and flavonoids. Moreover, the same authors, treating these diabetic rats significantly increased and ameliorated all kidney functions parameters. In fact, M. Oleifera seeds ameliorated liver fibrosis in rats reducing liver damage and symptoms of liver fibrosis, decrease the CCl4-induced elevation of serum aminotransferase activities and globulin level as well as reduce the elevated hepatic hydroxyproline content and myeloperoxidase activity (Hamza ) improving the indices of hepatoxicity in rats, such as malonialdehyde level and total antioxidant capacity, glutathione content, catalase, and superoxide dismutase activities (Hamza ).

Treatment with M. oleifera seeds also altered oxidative stress in relation to its anti-inflammatory activity. Histopathological observations showed mild or less infiltration of lymphocytes, angiogenesis and synovial lining thickening. From all above results and observations, it can be concluded that the seeds possess promising antiarthritic property (Mahajan et al. ).

These seeds have others appeals to the daily life and industry. Seed powder showed capacity to purify water and remove heavy metals and organic compounds (Sharma et al. ) through low molecular weight cationic proteins mediated precipitation (Kansal and Kumari ). There was a reduction of 80–99.5% in the turbidity of the water and 90–99.99% of bacterial reduction (Bhargave ; Lea ). The remaining paste after the oil extraction still has the same flocculation properties, serving both purposes and adding value (Lea ). Compounds such as pterygospermin, moringine and benzyl isothiocyanate isolated from M. oleifera seeds showed antimicrobial effect (Viera et al. ). Accordingly, there is applicability for M. oleifera seeds in the prevention of microbial diseases (Table (Table5).5). M. oleifera oil has also been tested for its potential to produce biodiesel, contributing as an alternative to the conventional diesel fuel (Rashid et al. ).

Flowers and roots

M. oleifera flowers are used directly as part of the diet, but also to make infusions which have hypocholesterolemic properties (Gopalakrishnan ) (Table (Table5).5). The flowers can also be a source of nectar and are used to produce honey (Gopalakrishnan ). A methanol extract of M. oleifera flowers revealed anti-cancer properties by inhibiting growth of PC3 cells (androgen-independent model of prostate cancer) in a dose-dependent manner, while not affecting the viability of normal cells (Inbathamizh ). According general evaluation by Fahey (, ) and (Divya et al. (), also supporting on several researches (e.g., Delaveau Boiteau ; Hameed et al. ; Faizi et al. ; Fuglie ) it is possible to attribute several relevant effects based on the M. oleifera flower treatments which consist in: general disorders as tonic and anti- catarrh; antimicrobial—bacterial and viral Infection; against helminths parasites, external sores, ulcers and fever; nervous disorders as hysteria; anti-tumor in cancer therapy; diuretic in endocrine and circulatory disorders; anti-rheumatism in inflammation processes. So, it could be added to industrial products in order to provide healthier products to the consumers (Guiger et al. ; Gopalakrishnan et al. ). M. oleifera roots and flowers extracts revealed hepatoprotective effect on rat paracetamol—induced hepatotoxicity (Ruckmani ). Roots also showed antiinflamatory effect on animal model of induced hind paw edema and antimicrobial activity (Cáceres ; Ruckmani ). An aqueous extract of M. oleifera roots when given orally to rats, in a dose-dependent manner, influenced the hormone balance necessary to gestation, leading to an anti-implantation effect (Shukla et al. ). A study with an ethanolic root bark extract showed antiulcer, antisecretory (reducing gastric acid secretion), and cytoprotective action in rats with gastric ulceration (Table (Table5).5). The extract dosage of 500 mg/kg showed the highest protection in the both ulcer models studied (ethanol-induced and pylorus ligation-induced gastric ulceration) (Choudhary et al. ). The alkaloids (moringine, moringinine), saponins, triterpenoids and tannins present in M. oleifera appear to be the plant compounds with antiulcer activity and conferring protective capacity through diverse mechanisms (Choudhary et al. ). Anti-inflammatory action was also verified by a methanol extract of M. oleifera roots in rat paw edema models (Ezeamuzie et al. ) (Table (Table5).5). Moringa root wood reduced the elevated urinary oxalate and lowered the deposition of stone forming constituents in the kidneys of calculogenic rats as a result of ethylene glycol treatment (Karadi et al. ).


The bark also has antimicrobial properties (Table (Table5).5). Root bark extracts by ethanol, methanol and distilled water showed antifungal activity against Neurospora crassa and Aspergilus niger, in which the higher the concentration, the higher mycelial inhibition, with a duration up to 96 h (Jha ). Antibacterial activity was also verified in a study with methanol, chloroform, ethyl actetate and water bark extracts. Staphylococcus aureus, Citrobacter freundii, Bacillus megaterium and Pseudomonas fluorescens growth was inhibited by all extracts in different concentrations and in different degrees (Zaffer et al. ). The presence of flocculating proteins of bark and roots might be part of the antimicrobial mechanism (Wang et al. ). A clinical study with 30 patients proved that 40 mL of stem bark decoction, twice a day, was effective in treating symptoms of urinary tract infection. (Maurya and Singh ). However, studies with larger samples are needed to access the viability of M. oleifera use in this and other pathologies. Hepatoprotective effect (Kurma ), anticholesteremic and antilipidemic activity (Senecha ) was also verified in rat model with different extracts of M. oleifera bark (Table (Table55).

Therapeutic considerations based on traditional Asian medicines

Traditional ayurvedic medicine

In terms of medicinal value, India's traditional ancient Ayurvedic Medicine has identified more than 300 diseases that could be cured with the different parts of M. oleifera, such as leaves, roots, bark, flowers and seeds. In order to better understand the traditional therapeutic effects of M. oleifera, according to the principles of Ayurvedic Medicine, we have to consider two main constitutional conditions for individuals, the Vata and Kafta constitution (Miller ; Ninivaggi ). Vata constitution embodies the energy of movement and is therefore often associated with wind and the air element. Vata is represented by the movement in the body, and manifests itself as the movement of nerve electric impulses, air, blood, food, waste and thoughts. Vata is linked to creativity and flexibility; it governs all movements and when unbalanced can lead to both physical and energetic exhaustion, causing all sorts of abnormal movements in the body, such as tics, tremors, and muscle spasms. Vata has seven characteristics, which are: cold, light, irregular, mobile, rarefied, dry, and rough. These qualities characterize their effect on the body. When there is excess of Vata, force can cause nerve irritation, high blood pressure, gas and confusion. Deficiency of Vata, causes congestion, constipation and thoughtlessness (Miller ).

Kapha constitution is related with solidity and structural cohesiveness of all things that holds things together, and is mainly associated with the earth and water elements. At one level, Kapha is represented by the cells which make up our organs and the fluids which nourish and protect them. Emotionally Kapha embodies the energies of love and compassion, which are related to water element. When out of balance, kapha have the tendency to create physically stagnation and congestion in organs and tissues in the body, including at the mind level. Excess of Kapha causes the tendency to produce mucous and obstruction in the sinus and nasal passages, the lungs and colon. At the level of the mind it creates rigidity, a fixation of thought, inflexibility. Deficiency of Kapha causes the body to experience a dry respiratory tract, burning stomach sensation (due to lack of mucous in the wall of stomach that gives protection from excess hydrochloric acid), and inability to concentrate the mind. Kapha force is described according to the following qualities: oily, heavy, stable, dense and smooth (Miller ; Ninivaggi ).


The somatic properties of M. oleifera

According to the Traditional Ayurvedic Medicine, the somatic properties and uses of the different parts of M. oleifera is expected to have several and specific effects depending on the somatic expression of patient, and its energetic Vata or Kapha constitution. The energetic and pharmacological actions as well as clinical uses, roots, barks, leaves and seeds are described in Table Table66 and  below:

Table 6

Traditional Ayurvedic medicinal uses, pharmacological actions, clinical uses, psychological effects, of different parts of M. oleifera Lam (Swati ; Warrier )

Ayurvedic medicinal properties, pharmacological actions and uses of M. oleifera
Roots Bark Leaves Seeds Flowers
Temperature and taste Bitter, acrid, thermogenic (Warrier ) Acrid, bitter, thermogenic (Warrier ) Bitter, cold effect (Warrier ) Acrid, bitter, cold effect (Warrier )
Traditional uses Unbalanced conditions of vata and kapha (Warrier ) Unbalanced conditions of vata and kapha (Warrier ) Unbalanced conditions of vata and kapha (Warrier ) Unbalanced conditions of vata and kapha, (Warrier ) Unbalanced conditions of vata and kapha, (Warrier )
Pharmacological actions Digestive, carminative, anthelmintic, antilithic constipating, anodyne, analgesic, emmenagogue, sudorific, diuretic, rubefacient, ophthalmic, anti-inflammatory expectorant, hematinic, alexipharmic (antidote to poison), stimulant and vesicant, cardiotonic, antiepileptic, anti-asthmatic (Warrier ) Antilithic, carminative rubefacient, vesicant, antifertility, anti-inflammatory, anti-rheumatic, cardiotonic (Swati ) Abortifacient, antifungal, cardiotonic, antiparasitic (Warrier ) Rubefacient, vesicant, anti-tumor (Swati ) Analgesic, anodyne, anti-inflammatory, anthelmintic, ophthalmic (Warrier ) Antipiretic Anti-diabetic (Swati ) Analgesic, anti-inflammatory, antipyretic, purgative, anthelmintic, anti-diabetic, ophthalmic, anti-hypertensive (Warrier ) Cholagogue, stimulant, diuretic (Warrier )
Clinical uses Dyspepsia, anorexia, verminosis, diarrhea, colic, flatulence, otalgia, paralysis, inflammations, amenorrhea, dysmenorrhea, fever, strangury, vesical and renal calculi, ascites, ophthalmopathy, cough, asthma, bronchitis, cardiopathy, pectoral diseases, abcess and pharyngodynia, fatigue, anxiety, hepatomegaly, splenomegaly, epilepsy, hysteria (Warrier ) Stimulant in paralytic afflictions, act as cardiac/circulatory tonic. Treating rheumatism, inflammations and articular pains (Swati ) Ringworm, ascites, cardiac and circulatory stimulant, fungal diseases (Warrier ) Eye diseases, delirious, prevent enlargement of spleen and formation of tuberculous glands of neck, destroy tumors, and heal ulcers (Swati  Scurvy, wounds, tumors, inflammations, helminthiasis (Warrier ) Purgative, hemorrhoids, wounds, sore throat, headaches, bronchitis, eye and ear infections, scuvy and catarrh (Swati ) Neuralgia, inflammations, intermittent fevers, ophthalmopathy, hypertension (Warrier ) Stimulant, aphrodisiac, abortifacient, digestive problems, hysteria, anti-tumors, anti-ulcer, splenomegaly and swollen lymph nodes and glands of neck, decrease serum cholesterol, phospholipid, triglycerides, cholesterol, triglycerideos, VDLDL, LDL (Swati )
Psychological effects Mildly calming and grounding Enhance feelings of serenity and balance as well as helping to keep one centered in times of change or uncertainty (Warrier ) Restore self-confidence and address indecisiveness Mental clarity Contribute to a feeling of certainty and assuredness (Warrier ) Anti-depression, mind lifting power and overcome feelings of hopelessness. Renew the spirit and reinvigorate the body mentally and emotionally (Warrier ) Anti-depression, mind lifting power and overcome feelings of hopelessness. Renew the spirit and reinvigorate the body mentally and emotionally (Warrier ) Helping to let go of memories, guilt, emotional wounds and traumas. Encourage positive thinking and a renewed outlook on life (Warrier )

Root Bitter, acrid, thermogenic, digestive, carminative, anthelmintic, constipating, anodyne, anti-inflammatory, emmenagogue, sudorific, diuretic, ophthalmic, rubefacient, expectorant, hematinic, antilithic, alexipharmic, stimulant and vesicant. They are useful to equilibrate the unbalance physical conditions of vata and kaphta constitutions with manifestations of dyspepsia, anorexia, verminosis, diarrhea, colic, flatulence, otalgia, paralysis, inflammations, amenorrhea, dysmenorrhea, fever, strangury, vesical and renal calculi, ascites, ophthalmopathy, cough, asthma, cardiopathy, abscess and pharyngodynia (Warrier ).

Bark Acrid, bitter, thermogenic, abortifacient, antifungal, cardiac and circulatory stimulant. It is useful in ascites, vitiated conditions of vata and kapha and ringworm.

Leaves Bitter taste, cold nature, anti-inflammatory, anodyne, anthelmintic, ophthalmic and rich in vitamins A and C. They are useful in scurvy, vitiated conditions of kapha and vata, wounds, tumors, inflammations and helminthiasis.

Seeds Acrid and bitter taste, cold nature, anodyne, anti-inflammatory, purgative, antipyretic and ophthalmic. They are useful in neuralgia, inflammations, intermittent fevers and ophthalmopathy (Warrier ).


The psychological and spiritual properties of M. oleifera

Concerning Ayurvedic ancient texts, is mentioned the psychological and spiritual properties of M. oleifera, which is described as powerful herb that penetrates the deep layers of body’s tissues and particularly into the bone marrow, which is the deepest tissues of all. Moringa oleifera has a powerful action in purifying the blood, removing impurities, toxins, parasites and metabolic wastes, helping to rejuvenate cells.

Moringa oleifera acts and influences at mental, emotional, energetic and spiritual level altogether, having a strong effect in the personality.

In terms of influencing the mind, M. oleifera was tested by scientific research, which proved to have anti-depressive and anxiolytic effects (Kaur et al. ), as well considered an adaptogenic and anti-stress herb (Drue ).

Leaves The leaves remarkable nutritional properties, are said to restore self-confidence and address indecisiveness. Ancient ayurvedic physicians also used the leaves to bring clarity and restore the body at deep levels, which both contribute to a feeling of certainty, courage and fearless.

Root The roots of the plant are said to be mildly calming and grounding, as is often the case with root medicines. The root is known to enhance feelings of serenity and balance as well as helping to keep one centered in times of change or uncertainty.

Seeds The seeds of the plant were used as a remedy for depression in ancient India, referred for their ability to give energy and overcome feelings of hopelessness. The seeds were considered tonifying and were believed to renew the spirit and reinvigorate the body, as well as the mind and emotions (Warrier ).

Flowers The flowers were believed to be beneficial and effective for helping to let go of traumatic memories that obstructed the mind, guilt, emotional wounds and phobias. M. oleifera flowers are said to encourage positive thinking and to renew the view on life, bringing light to the spirit (Warrier ).

Traditional Chinese medicine—TCM

Moringa oleifera is a native plant in the Himalayas and is found in the Chinese herbal medicine dictionary in China, although it is not noted in the TCM classical herbal books, and it’s not considered a commonly used Chinese herb. However, a variant with wingless seeds has been collected in S Yunnan (Xishuangbanna Dai Zu Zizhizhou). In China, M. Oleiferae was introduced from India in the 1960s and had been cultivated on a large scale for ornament and distributed in southern provinces such us Guangdong, Taiwan and Yunnan, where is known as = lamu 辣木 (Mandarin) (Chen; Wan ; Zhang and Hengshan ).

Although, the nutritional value is important, according to the TCM principles it gives more importance to temperature and taste properties of herbs or food in order to determine if it is suitable for an individual with a certain temperature and constitutional tendency (Ross ).The most consumed part of M. oleifera are the leaves which present bitter and sweet taste, have a descending effect or downward movement and cooling property (Dong et al. ). Since M. oleifera leaves has cooling properties, it may not be suitable for everyone, especially to those persons who are cold constitution or yang deficiency, that normally are feeling cold, less active, tired, and other symptoms belonging to cold syndrome diseases.

Based on TCM concepts, Jing, which is translated as our bodies ‘vital essence’ or ‘deep life force’, is strongly related to bone marrow, and so being the marrow a manifestation of Jing essence in the body (Ross ). Moringa oleifera leaves, as demonstrated by their ability to reverse severe malnutrition, is a potent rebuilder of marrow in the body, essentially restoring life force energy at an extraordinarily deep level (Gopalakrishnan, ), influencing the behavior and mental level with positive mood, by giving will power, energetic and cheerful attitude towards life.

According to traditional Chinese medicine (TCM) principles different parts of the Moringa tree have different energetic functions (Table 7):

Table 7

Traditional Chinese medicinal uses according to temperature, taste and traditional actions, pharmacological actions, clinical uses, psychological effects, of different parts of M. oleifera Lam (Brown ; Ronglin and Qiuxiu ; Litao and Hongmin ; Dong ; Shao et al. )

Traditional Chinese medicine properties, pharmacological actions, clinical uses and psychological effects of M. oleifera Lam
Roots Bark Leaves Seeds
Temperature, taste and Traditional actions Acrid taste (have an ascending effect) and warming effect (Litao and Hongmin  ) (Ronglin and Qiuxiu ) Eliminate wind, Strengthen the Stomach and Spleen support Yang (Dong et al. ) Acrid taste (have an ascending effect) and warming effect (Litao and Hongmin ) (Ronglin and Qiuxiu ) Eliminate wind, Strengthen the Stomach, Spleen and support Yang (Dong et al. ) Sweet and bitter taste (have a descending effect) and cold effect (Litao and Hongmin ) (Ronglin and Qiuxiu ) Eliminate dampness and turbid stagnated phlegm, expel heat and remove toxins. Tonify spleen and stomach, reduce hyperactivity liver yang (Dong et al. ) Acrid and bitter taste (have a ascending effect) and warming effect (Litao and Hongmin ) (Ronglin and Qiuxiu ) Tonify the Spleen and eliminate dampness (Dong et al. )
Pharmacological actions Diuretic, anti-migraine, anti-diarrhea (Litao and Hongmin ) Anti-anemic, immune stimulant. (Brown ) Laxative, anti-hypertensive (Litao and Hongmin) Hypoglycemic, hypolipidemic, analgesic (Dong et al. ) Appetite stimulant, anti-flatulence, diuretic (Brown )
Clinical uses Edemas, headaches, dizziness, gastrointestinal problems, flatulence, high blood pressure (Litao and Hongmin  ) (Brown ) Gynecological problems such as vaginitis, excess discharge (Brown ) Hyperthyroidism (Shao et al. ) Diabetes, inflammation hypertension, pain constipation (Litao and Hongmin ) Low appetite, flatulence, bloating, heavy sensation in the limbs, edemas (Brown )
Psychological effects Essentially restoring life force energy at an extraordinarily deep level. Influencing the behavior and mental level as well by giving will power, energetic and cheerful attitude towards life (Brown )

Seeds and fruit Tonify the Spleen and eliminate dampness. Recommended for people with low appetite, bloating, heavy sensation in the limbs (Brown ). An oil is extracted from the seeds, which also contain a powerful flocculant that can be used to clarify turbid water.

Root The root has an acrid and pungent taste and warm nature, like the leaves and young fruits, are used for food.

Root and bark The root and bark eliminate wind, strengthen the stomach and spleen, support Yang and promote urination. It is recommended for headaches, dizziness, gastrointestinal problems, flatulence, high blood pressure, skin problems. (Brown ).

Leaves This most used part has an ability for reversing severe malnutrition eliminating dampness and heat as well as expelling toxins. It is recommended for gynecological problems such as vaginitis, excess discharge. It is also rich in iron, hence it can be used for anemic to tonify the blood (Brown ). According to the scientific research suggestions (Dong et al. ) and combined with the taste theory of TCM, we can speculated that M. oleifera leaves have cold property, sweet and bitter taste, redirected to the liver, spleen and/or stomach meridians.

In general, M. oleifera leaves according to TCM view, nourishes the earth element that is related to the spleen and stomach. Energetically is responsible in producing blood, directly linked to thoughts mechanism and mind activity. It works in the body as an astringent way by maintaining the blood in the vessels, governing the muscles, and act in the memory level (Liu ; Ross ). The main organ of Earth element is the spleen, and its responsible to remove the Gu Qi (Pure Energy) of the foods and send it to other organs to produce other pure substances like the Wei Qi (Defensive Energy) related to the immune system, Xue (Blood), and normal Qi (Energy) that circulates in the body meridians (Botsaris ; Ross ). The regular intake of M. oleifera can greatly benefit this important energetic organ in TCM, contributing for great performance of earth element in the body.

Cold nature—Analyzing deeply the energetic categorization of M. oleifera according to TCM principles, it can be said that, natural compounds presenting an inhibition role on the body’s metabolism, are generally considered to have cold nature, while inflammation, high blood pressure, diabetes, constipation, etc. are also considered to be mainly Yang and belong to excess syndrome diseases. Moringa oleifera leaf, it is also considered to be anti-inflammatory, antihypertensive, hypoglycemic, laxative and other functions effect as well, leading Dong et al. () to infer that M. oleifera leaf is cold. According to the study of phytochemical properties and its compatibility analysis, M. oleifera leaves are rich in alkaloids and has anti-inflammatory effects which confer similar nature as cold medicinal plants (Liwu et al. ; Leone et al. ). Additionally, the research study in M. oleifera based on analysis and comparison of trace elements, as calcium, sodium, potassium, phosphorus, magnesium, manganese, copper, iron, zinc and selenium in order to categorize under cold or hot nature TCM concept (Ronglin and Qiuxiu ; Olson et al. ), also shows that M. oleifera has strong evidence as cold medicinal plant.

Bitter or sweet taste—Curiously, most of the medicinal plants with cold nature present bitter taste, with pharmacological actions of antipyretic, antibacterial, antiviral, etc. effects (Ali et al. 2018). Currently, there are no deep studies on the taste of M. oleifera leaves but, it is believed according to its action, uses and the TCM theory of five flavors, that it has sweet and bitter taste. This means that, while sweet taste drugs can replenish, reconcile, promote smelting, nourish, tonify and relieve pain, bitter taste drugs can release, dry, clear the heat and purge the fire, induce venting, reversing energy (qi) and moving stool. Most of medicinal plants that store yin (organic substance) has a bitter taste with laxative action softening of hard stools and reducing infectious diseases with the cooling effect. Moringa oleifera leaves can also decrease fat in blood and promote weight loss, which is also according to its bitter taste. Moringa oleifera fresh leaves have acrid and bitter taste, while the dried M. oleifera powder has a lighter taste and less bitter taste. Moreover, the modern research indicates that in bitter medicinal plants contain mostly alkaloids and glycosides, although, having sour ingredients, mainly phenolic acid, tannin, etc.

In general, all these aspects may suggest that M. oleifera presents natural compounds with manly antipyretic, qi-releasing, clearing heat, laxative, replenishing and blood-activating effects.

On the other hand, the sweet taste in medicinal plants means that contains many sugars, glycosides, amino acids, proteins and vitamins. Moringa oleifera leaves contain rich nutritional value and can be used to nourish children that has severe malnutrition and lack of trace elements, so being inferred as a tonic effect plant. In addition, studies have shown that methanol extract from M. oleifera leaves presents obvious analgesic effect (Adedapo et al. ) which agree to the most analgesic natural drugs compounds that have sweet taste. Moringa oleifera leaves with reducing role of the body's inflammatory response can treat malaria, typhoid, etc. (Waterman et al. ; Udosen et al. ; Donkor et al. ; Dondee et al. ). Finally, although not present in M. oleifera, salty natural drugs often contain inorganic salts and proteins (Zhang and Liu ) which can dissipate nodules, light, permeable, and water-wetting drugs, maintaining and retaining humidity, whereas the acid drugs can receive, astringent, and generally stop sweating, constricting lungs, cough, astringent intestines, diarrhea, urine.

In summary, the above natural effects described in research are consistent with the nutritional, tonic and analgesic efficacy of sweet natural medicinal drugs.

Energetic meridian tropism—TCM medicinal plants are energetically categorized in by its nature or temperature, taste, movement with ascend or descend effect and meridian organ tropism. Ascend and descend movements will demonstrate if the herb has an upward or floatation in preference to a downward or sedimentation effect in the body. Concerning M. oleifera leaves it is believed to have cold and bitter tastes (Litao and Hongmin ), having antihypertensive effect and promoting defecation, considering that we may speculate that M. oleifera belongs to sedimentation drugs with downward or descendent movement.

The meridian organ tropism is mainly inferred by the action of M. oleifera leaves having the effect of treating liver dysfunction and lowering blood pressure, which can be attributed to the liver meridian. M. oleifera leaves also stimulate lactation, which is related with liver and/or stomach meridians.

In terms of western medicine clinical uses, M. oleifera leaves can treat malnutrition, obesity, and lipid-lowering effects (Jain et al. ). Those are closely related to the spleen meridian. Therefore, it is a strong possibility that M. oleifera leaf actions belong to the liver, spleen and/or stomach meridians.

Through the 238 kinds of analysis of flavored drugs, Wang () found that sweet flavored natural drugs mostly are related to the liver, lung and stomach meridians; the bitter taste medicines are mostly redirected to the liver and stomach meridians; the acid drugs are mostly redirected to the liver, stomach, lung and spleen meridians; salty drugs mostly belongs to liver and kidney meridians. So, since M. oleifera leaves exhibit sweet and bitter flavor, this reinforce clearly its action on the liver, spleen and/or stomach meridian as well as its beneficial effect on treating malnutrition and on regulating blood sugar levels in people with diabetes which is mostly qi-yin deficiency in TCM energetic syndrome differentiation. According to TCM categorization spleen and stomach meridians belong to earth element.

Moringa oleifera leaves are cold, which has anti-inflammatory effect, lowering the fever, can also reduce the body’s metabolism, therefore allowing to speculated that M. oleifera leaves have a cooling effect in the body. M. oleifera leaves also have a lipid-lowering, weight-loss, and arterial plaque improvement. On the other hand, in TCM system a pharmacological action on the obesity and arterial plaque is mostly considered to exhibit a manifestation on phlegm and so, M. oleifera leaves may have a dehumidifying effect, eliminating dampness and phlegm. The prevention and management of hypertension are major public-health challenges (Qi Hua et al. ), being TCM herbs regularly advocated for lowering elevated blood pressure needing a new understanding between ancient and modern times treatment on this subject (Xiong et al. ). Moringa oleifera leaves can reduce blood pressure and protect liver and kidney (Leone et al. , ). In TCM system the cause of hypertension is mainly due to hyperactivity of liver yang, phlegm and turbidity (Shao et al. ). The heat-relieving properties of M. oleifera leaves, clear the liver meridian heat removing phlegm and redirect energy to the spleen and/or stomach meridians, also strengthen the spleen and eliminate the dampness.

Curiously, attending the new global and dramatic situation concerning the corona-virus, Yang (), vice-leader of the Chinese Expert Medical Group for fighting Covid-19 in Italy, said in a recent international videoconference, that modern Chinese medical doctors putted forward a new concept to combat and block this pulmonary disease. This concept propose the use of heavy dose bitter and cold herbs in order to clear heat and detoxify purging the infection in the early stage as well as to cool blood and remove blood stasis promptly in the middle and late stages. So, according all properties described above mainly to the leaf part of M. oleifera, such as sweet and bitter taste, cold, venting and dehumidifying inductor with descendent effect, can also make it an eventual and excellent candidate for treating the general deep alterations in immunological system involved in this disease. Moreover, all symptoms concerning hypertension, cardiovascular disease, diabetes, obesity, lung disease/asthma, kidney disease, liver disease, hematological disorders/anemia, when associated to the Covid-19 infection, will complicate intense and seriously the organism health. So, having present all immunological and specific properties and applications already inferred to M. oleifera, it is possible to speculate an adequate and supportive therapy in the corona-virus infection when combined with western medicine.

In summary, M. oleifera due to the above TCM properties can treat hyperthyroidism caused by hyperpyrexia of liver, clearing liver fire and phlegm-dampness; hypertension caused by excessive rising of liver yang or retention of phlegmatic dampness; phlegm, obesity and diabetes caused by spleen deficiency and phlegm turbid stagnation (Inbathamizh ; Al-Asmari et al. ; Gopalakrishnan et al. ; Fahey ; Dong et al. ). All these pathologies that benefit with M. oleifera treatment allow us to infer and confirm its TCM specific properties (Tables (Tables6,6, ,7).7).

Important to notice that Ayurvedic tradition have a more detailed and rich description about the pharmacological actions and clinical uses, as well as psychological effects of the different parts of M. oleifera, suggesting a much longer tradition using this plant in their daily life in Indian continent population. Moringa oleifera was only introduced to China from India in the 1960s and had been cultivated on a large scale for ornament in southern provinces of China. So, it is quite understandable that India possess much more traditional and scientific medical knowledge about M. oleifera than in Chinese culture. Although only recently introduced to China, due to its valuable medicinal properties, TCM experts recognize its value and categorize it according to their own principles, so that can be clinically used as a TCM natural drug.

In this literature research about M. oleifera in both ancient systems of medicine (India and China) we could observe some common views about this tree.

In both traditional culture the roots and bark of M. oleifera are considered acrid and warm in temperature, being appropriated to treat constitutional deficiency type. But, based in TCM concepts, its leaves are considered of bitter, sweet and cold nature which can be used in excess energetic syndromes, such us hyperthyroidism, hypertension, inflammations, fever, diabetes, constipation, etc. On another side, supported on trace elements and organic compounds (mentioned above), its leaves contain rich nutritional value since that, according TCM principles, has a tonifying effect of the spleen and stomach increasing the absorption and nutrients transport, which is indicated for the lack of energy and internal dampness being beneficial to tiredness, malnutrition, digestive problems, low appetite and anemic states.

Based on TCM principles, one can state that the most predominant action of M. oleifera leaves is to treat excess syndrome diseases mainly supported by its bitter taste and cooling temperature effect, clearing the excess heat and phlegm from the liver meridian, but at same time can have a strengthening effect in spleen and stomach meridians due to the sweet taste which can also have a nourishing effect in the body.

In Ayurvedic Medicine tradition, M. oleifera roots are clinically used to treat epilepsy, hysteria, cardiac diseases, colic and flatulence, as well as anxiety. All these diseases correspond to an excess of Vatta, which force can cause nerve irritation, high blood pressure, flatulence and confusion.

Moringa oleifera leaves are clinically used to treat catarrh, bronchitis, sore throat, headaches, constipations, which corresponds to an excess of Kapha which causes the tendency to produce mucous and obstruction in the sinus and nasal passages, lungs and colon.

Moringa oleifera seeds are clinically used to treat hypertension, neuralgia indicating an excess of Vata, and to treat constipation which belongs to an excess of kapha.

Both traditional Asian medicines reported anti-inflammatory, analgesic, antiparasitic, anti-hypertensive, hypolipidemic, hypoglycemic, diuretic effects, and help in several gastro-intestinal, gynecological and dermatology problems. Anti-aging and strength immunity are also documented, mentioning both its potential in removing toxins from the body.

In terms of influencing the mind, M. oleifera, anti-depressive and anxiolytic effects was tested and confirmed by scientific research (Kaur et al. ). It was further considered an adaptogenic and anti-stress herb (Drue ). Modern research about Moringa is aligned with both Ayurvedica and Traditional Chinese Medicine tradition, proving that the leaves of Moringa are super nourishing of the body, as well reporting tremendous benefits in a wide range of diseases, having also the capacity in renewing the body tissues and reinvigorate the mind and promote a positive emotional state.

Therefore, we could say that M. oleifera leaves are a natural supplement that works well at all levels of health and wellbeing. Whether to nourish the body, treating and preventing many diseases, or as well used as cosmetics for skin, and contributing for an energetic and positive state of mind.


Moringa oleifera can be part on solving a variety of health problems, diseases, vitamins deficiency, malnutrition and, at the same time, being a useful natural resource to the population and industry. Recently, more studies have been done to identify M. oleifera proteins and their functions (Wang et al. ). However, for the most of the M. oleifera properties studied, the active molecules in the extracted compounds are still to be determined, as well as the mechanisms essential to explain the medicinal properties observed and the safety of the crude extracts. Therefore, M. oleifera deserves extensive investigation to better explain the mechanisms of action. The better understanding of M. oleifera composition and properties, as well as the isolation of active compounds, may attract attention to its usefulness in nutrition (as a health promoting supplement), for new drug development and other applications such as water purification (allowing a sustainable and low-cost water treatment), production of biodiesel and cosmetics. Therefore, increasing M. oleifera plantation in countries with scarce resources, both for popular use and for exportation of M. oleifera tree parts and byproducts, could boost the local trade and employment, since with correct information about the properties and cultivation rules (Bhargave ; Ojiako ). Citing Mahmood et al. (), M. oleifera is a “high quality gift of nature at very low price”. According to traditional Asian medicines different parts of M. oleifera has a very large and correct therapeutic applications which depend on diagnose concerning somatic, emotional and spiritual needs. In general, M. oleifera penetrates deeply into the body’s tissues and particularly into the bone marrow itself cleaning all impurities, toxins, parasites and metabolic wastes. This induces the renovation of cells influencing to the mind and personality with a high positive and confidence feelings. It is a potent rebuilder of marrow in the body, essentially restoring life force energy at an extraordinarily deep level.

Traditionally in TCM the leaves of M. oleifera are considered to be bitter and sweet with a descending and cooling effect, which can clear the excess heat and phlegm from the liver meridian, but at same time can have a strengthening effect in spleen and stomach meridians due to the sweet taste and rich nutritional value (Dong et al. ). In Ayurvedic Medicine, M. oleifera leaves among other diseases are clinically used to treat catarrh, bronchitis, sore throat, headaches, constipations, which corresponds to an excess of Kapha constitution type that normally causes the tendency to produce mucous and obstruction in the sinus and nasal passages, the lungs and colon (Miller ; Ninivaggi ). This study provides an integrative approach on conventional and traditional Asian medicine properties, nutritional and pharmaceutical applications of M. oleifera. So, comparatively, it seems possible to correlate concepts concerning Warm versus Vata effects and Cold versus Kapha effects in TCM and Ayurveda medicines, respectively, which can even add great value in confirming and completing any lack of therapeutic information.

Taking into consideration the empirical knowledge of traditional Asian medicine and their own paradigm-based medicine, future research studies are required to validate or understand their mechanism of energetic categorization and their actions, opening new ideas and horizons, as that on the Covid-19 disease effect, for a more correct, scientific and clinical application of M. oleifera.


We would like to thank Dr. Rodrigo Silva, a clinical consultant of Naturinga Company in Portugal, for its friendly help in stimulating our interest in this natural and medicinal plant. We thanks also Bruno Ramos of ICBAS-UP who kindly support the informatics assistance in the composition of table and manuscript format.


This research did not receive any specific Grant from funding agencies in the public, commercial, or not-for-profit sectors.

Compliance with ethical standards

Ethical statement

This article does not contain any studies with human participants or animals performed by any of the authors.

Conflict of interest

Diana Meireles has no conflict of interest. João Gomes has no conflict of interest. Lara Lopes has no conflict of interest. Mariana Hinzmann has no conflict of interest. Jorge Machado has no conflict of interest.



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Diana Meireles and João Gomes authors contributed equally to this work.



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